To create a harmonic with your pick hand, allow part of your thumb to touch the string as you pick it. This is done while holding the pick. As you pick the string, turn your thumb slightly down so that the outside edge of your thumb touches the string at the same time. This technique is best accentuated on an electric guitar with a good distortion. Practice this until you are impeccable at it!
Now, still using the pick hand harmonic technique, try bending your tremolo bar (whammy bar) up and down after you pluck the string. This is a great technique to really add some flavor and WOW to your soloing.